Guillaume Lessene* : rechercher sur Z-Library

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Articles (46)
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1

Total Synthesis of (−)-Spiroleucettadine

Lamb, Richard A., Aberle, Nicholas S., Lucas, Nigel T., Lessene, Guillaume, Hawkins, Bill C.

Journal:

Angewandte Chemie

Année:

2017

Langue:

english

Fichier:

PDF, 745 KB

english, 2017

2

The Synthesis of (–)-Spiroleucettadine

Lamb, Richard, Lessene, Guillaume, Hawkins, Bill

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 238 KB

english, 2018

3

ChemInform Abstract: Magnesium Bis(diisopropylamide), a Useful Reagent for Regio- and Stereoselective Synthesis of Kinetic Silyl Enol Ethers.

Guillaume Lessene, Regis Tripoli, Philippe Cazeau, Claude Biran, Michel Bordeau

Journal:

Année:

1999

Fichier:

PDF, 29 KB

1999

4

ChemInform Abstract: Selective Electrochemical Synthesis and Reactivity of Functional Benzylic Fluorosilylsynthons.

Philippe Clavel, Guillaume Lessene, Claude Biran, Michel Bordeau, Nicolas Roques, Stephane Trevin, Dominique de Montauzon

Journal:

Année:

2001

Fichier:

PDF, 28 KB

2001

5

Oxidative Aryl-Coupling Reactions in Synthesis

Guillaume Lessene, Ken S. Feldman

Journal:

Année:

2004

Fichier:

PDF, 54 KB

2004

6

ChemInform Abstract: Synthesis of Azide-Alkyne Fragments for “Click” Chemical Applications. Formation of Chiral 1,4-Disubstituted-(β-alkyl)-γ-1,2,3-triazole Scaffolds from Orthogonally Protected Chiral β-Alkyl-trialkylsilyl-γ-pentynyl Azides and Chiral β-Alkyl-γ-pentynyl-alcohols.

Oliver D. Montagnat, Guillaume Lessene, Andrew B. Hughes

Journal:

Année:

2011

Fichier:

PDF, 54 KB

2011

7

ChemInform Abstract: Benzoylureas as Removable cis Amide Inducers: Synthesis of Cyclic Amides via Ring Closing Metathesis (RCM).

Ryan M. Brady, Yelena Khakham, Guillaume Lessene, Jonathan B. Baell

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 34 KB

english, 2011

8

Synthesis of azide-alkyne fragments for ‘click’ chemical applications; formation of oligomers from orthogonally protected trialkylsilyl-propargyl azides and propargyl alcohols

Oliver D. Montagnat, Guillaume Lessene, Andrew B. Hughes

Journal:

Tetrahedron Letters

Année:

2006

Langue:

english

Fichier:

PDF, 132 KB

english, 2006

9

Spiroleucettadine: synthetic studies and investigations towards structural revision

Nicholas Aberle, Simon P.B. Ovenden, Guillaume Lessene, Keith G. Watson, Brian J. Smith

Journal:

Tetrahedron Letters

Année:

2007

Langue:

english

Fichier:

PDF, 346 KB

english, 2007

10

Towards the electroreduction of very weak acids

Guillaume Lessene*, Michel Bordeau*, Claude Biran, Dominique de Montauzon, Jacqueline Gerval

Journal:

Journal of Electroanalytical Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 108 KB

english, 2000

11

Selective electrochemical synthesis and reactivity of functional benzylic fluorosilylsynthons

Philippe Clavel, Guillaume Lessene, Claude Biran, Michel Bordeau, Nicolas Roques, Stéphane Trévin, Dominique de Montauzon

Journal:

Journal of Fluorine Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 250 KB

english, 2001

12

Magnesium bis(diisopropylamide), a useful reagent for regio- and stereoselective synthesis of kinetic silyl enol ethers

Guillaume Lessène, Régis Tripoli, Philippe Cazeau, Claude Biran, Michel Bordeau

Journal:

Tetrahedron Letters

Année:

1999

Langue:

english

Fichier:

PDF, 236 KB

english, 1999

13

BCL-2 family antagonists for cancer therapy

Lessene, Guillaume, Czabotar, Peter E., Colman, Peter M.

Journal:

Nature Reviews Drug Discovery

Année:

2008

Langue:

english

Fichier:

PDF, 841 KB

english, 2008

14

Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors)

Yumiko Hirokawa, Alexander Levitzki, Guillaume Lessene, Jonathan Baell, Yi Xiao, Hongjian Zhu, Hiroshi Maruta

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 295 KB

english, 2007

15

A Concise Total Synthesis of Naamidine A

Aberle, Nicholas S., Lessene, Guillaume, Watson, Keith G.

Journal:

Organic Letters

Année:

2006

Langue:

english

Fichier:

PDF, 77 KB

english, 2006

16

Synthesis of Azide-Alkyne Fragments for “Click” Chemical Applications. Part 2. Formation of Oligomers from Orthogonally Protected Chiral Trialkylsilylhomopropargyl Azides and Homopropargyl Alcohols

Montagnat, Oliver D., Lessene, Guillaume, Hughes, Andrew B.

Journal:

Journal of Organic Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 1.88 MB

english, 2010

17

Crystallization and preliminary X-ray characterization of Epstein–Barr virus BHRF1 in complex with a benzoylurea peptidomimetic

Caria, Sofia, Chugh, Srishti, Nhu, Duong, Lessene, Guillaume, Kvansakul, Marc

Journal:

Acta Crystallographica Section F Structural Biology and Crystallization Communications

Année:

2012

Langue:

english

Fichier:

PDF, 349 KB

english, 2012

18

Characterization of the Two Fundamental Conformations of Benzoylureas and Elucidation of the Factors That Facilitate Their Conformational Interchange

Lessene, Guillaume, Smith, Brian J., Gable, Robert W., Baell, Jonathan B.

Journal:

Journal of Organic Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2009

19

Structure-guided design of a selective BCL-XL inhibitor

Lessene, Guillaume, Czabotar, Peter E, Sleebs, Brad E, Zobel, Kerry, Lowes, Kym N, Adams, Jerry M, Baell, Jonathan B, Colman, Peter M, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Gibbons, P

Journal:

Nature Chemical Biology

Année:

2013

Langue:

english

Fichier:

PDF, 1.54 MB

english, 2013

20

Synthesis of conformationally constrained benzoylureas as BH3-mimetics

Brady, Ryan M., Hatzis, Effie, Connor, Theresa, Street, Ian P., Baell, Jonathan B., Lessene, Guillaume

Journal:

Organic & Biomolecular Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 504 KB

english, 2012

21

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

Sleebs, Brad E., Czabotar, Peter E., Fairbrother, Wayne J., Fairlie, W. Douglas, Flygare, John A., Huang, David C. S., Kersten, Wilhelmus J. A., Koehler, Michael F. T., Lessene, Guillaume, Lowes, Kym,

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 2.81 MB

english, 2011

22

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Czabotar, Peter E., Lessene, Guillaume, Strasser, Andreas, Adams, Jerry M.

Journal:

Nature Reviews Molecular Cell Biology

Année:

2013

Langue:

english

Fichier:

PDF, 1.74 MB

english, 2013

23

Diazonamide Synthesis Studies: Use of Negishi Coupling to Fashion Diazonamide-Related Biaryls with Defined Axial Chirality

Feldman, Ken S., Eastman, Kyle J., Lessene, Guillaume

Journal:

Organic Letters

Année:

2002

Langue:

english

Fichier:

PDF, 113 KB

english, 2002

24

Dual role of Src kinase in governing neuronal survival

Iqbal Hossain, M., Hoque, Ashfaqul, Lessene, Guillaume, Aizuddin Kamaruddin, M., Chu, Percy W.Y., Ng, Ivan H.W., Irtegun, Sevgi, Ng, Dominic C.H., Bogoyevitch, Marie A., Burgess, Antony W., Hill, Andr

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 5.40 MB

english, 2015

25

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

White, Michael J., McArthur, Kate, Metcalf, Donald, Lane, Rachael M., Cambier, John C., Herold, Marco J., van Delft, Mark F., Bedoui, Sammy, Lessene, Guillaume, Ritchie, Matthew E., Huang, David C.S.,

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 2.57 MB

english, 2014

26

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

Murphy, James M., Lucet, Isabelle S., Hildebrand, Joanne M., Tanzer, Maria C., Young, Samuel N., Sharma, Pooja, Lessene, Guillaume, Alexander, Warren S., Babon, Jeffrey J., Silke, John, Czabotar, Pete

Journal:

Biochemical Journal

Année:

2014

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2014

27

Advances in the Negishi Coupling

Lessene, Guillaume

Journal:

Australian Journal of Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 73 KB

english, 2004

28

Targeting cell death pathways with small molecules: playing with life and death at the cellular level to treat diseases

Lessene, Guillaume

Journal:

Future Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2015

29

Exploiting the Biginelli reaction: nitrogen-rich pyrimidine-based tercyclic alpha-helix mimetics

Lim, Zelong, Duggan, Peter J., San Wan, Soo, Lessene, Guillaume, Meyer, Adam G., Tuck, Kellie L.

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 832 KB

english, 2015

30

Synthesis of Azide-alkyne Fragments for 'Click' Chemical Applications. Formation of Chiral 1,4-Disubstituted-(β-alkyl)-γ-1,2,3-triazole Scaffolds from Orthogonally Protected Chiral β-Alkyl-trialkylsilyl-γ-pentynyl Azides and Chiral β-Alkyl-γ-pentynyl-alcohols

Montagnat, Oliver D., Lessene, Guillaume, Hughes, Andrew B.

Journal:

Australian Journal of Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 392 KB

english, 2010

31

Small molecules targeting Mcl-1: The search for a silver bullet in cancer therapy

Nhu, Duong, Lessene, Guillaume, Huang, David C.S., Burns, Christopher J

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2016

32

The Tyr-Kinase Inhibitor AG879, that Blocks the ETK-PAK1 Interaction, Suppresses the RAS-induced PAK1 Activation and Malignant Transformation

He, Hong, Hirokawa, Yumiko, Gazit, Aviv, Yamashita, Yoshihiro, Mano, Hiroyuki, Kawakami, Yuko, Kawakami, Toshiaki, Hsieh, Ching-Yi, Kung, Hsing-Jien, Lessene, Guillaume, Baell, Jonathan, Levitzki, Ale

Journal:

Cancer Biology & Therapy

Année:

2004

Langue:

english

Fichier:

PDF, 265 KB

english, 2004

33

BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux

Reljic, Boris, Conos, Stephanie, Lee, Erinna F., Garnier, Jean-Marc, Dong, Li, Lessene, Guillaume, Fairlie, W. Douglas, Vaux, David L., Lindqvist, Lisa M.

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 1.85 MB

english, 2016

34

ID: 48

Poh, Ashleigh Ren-yi, Lessene, Guillaume, Khakham, Yelena, Masson, Frederic, Preaudet, Adele, Putoczki, Tracy, O’Donoghue, Robert, Ernst, Matthias

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 44 KB

english, 2015

35

BACE Inhibitors as Potential Drugs for the Treatment of Alzheimers Disease: Focus on Bioactivity

Evin, Genevieve, Lessene, Guillaume, Wilkins, Simon

Journal:

Recent Patents on CNS Drug Discovery

Année:

2011

Langue:

english

Fichier:

PDF, 297 KB

english, 2011

36

Bcl-2 Family Proteins as Therapeutic Targets

E. Czabotar, Peter, Lessene, Guillaume

Journal:

Current Pharmaceutical Design

Année:

2010

Langue:

english

Fichier:

PDF, 427 KB

english, 2010

37

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM

Rohrbeck, Leona, Gong, Jia-Nan, Lee, Erinna F, Kueh, Andrew J, Behren, Andreas, Tai, Lin, Lessene, Guillaume, Huang, David C S, Fairlie, Walter D, Strasser, Andreas, Herold, Marco J

Journal:

Cell Death & Differentiation

Année:

2016

Langue:

english

Fichier:

PDF, 1.47 MB

english, 2016

38

Analysis of Ca 2+ mediated signalling regulating Toxoplasma infectivity reveals complex relationships between key molecules

Stewart, Rebecca J., Whitehead, Lachlan, Nijagal, Brunda, Sleebs, Brad E., Lessene, Guillaume, McConville, Malcolm J, Rogers, Kelly L., Tonkin, Christopher J.

Journal:

Cellular Microbiology

Année:

2016

Langue:

english

Fichier:

PDF, 4.58 MB

english, 2016

39

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

Poh, Ashleigh R., Love, Christopher G., Masson, Frederick, Preaudet, Adele, Tsui, Cary, Whitehead, Lachlan, Monard, Simon, Khakham, Yelena, Burstroem, Lotta, Lessene, Guillaume, Sieber, Oliver, Lowell

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 4.54 MB

english, 2017

40

Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition

Weeden, Clare E., Ah-Cann, Casey, Holik, Aliaksei Z., Pasquet, Julie, Garnier, Jean-Marc, Merino, Delphine, Lessene, Guillaume, Asselin-Labat, Marie-Liesse

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 4.20 MB

english, 2018

41

Strategies, Setbacks and Successes in the Synthesis of (-)-Spiroleucettadine

Lamb, Richard A, Lucas, Nigel T., Lessene, Guillaume, Hawkins, Bill Corey

Journal:

Journal of Organic Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 692 KB

english, 2018

42

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

Brennan, Margs S., Chang, Catherine, Tai, Lin, Lessene, Guillaume, Strasser, Andreas, Dewson, Grant, Kelly, Gemma L., Herold, Marco J.

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 1.78 MB

english, 2018

43

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

Merino, Delphine, Kelly, Gemma L., Lessene, Guillaume, Wei, Andrew H., Roberts, Andrew W., Strasser, Andreas

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 2.08 MB

english, 2018

44

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

Birkinshaw, Richard W., Gong, Jia-nan, Luo, Cindy S., Lio, Daisy, White, Christine A., Anderson, Mary Ann, Blombery, Piers, Lessene, Guillaume, Majewski, Ian J., Thijssen, Rachel, Roberts, Andrew W.,

Journal:

Nature Communications

Année:

2019

Langue:

english

Fichier:

PDF, 1.60 MB

english, 2019

45

IDENTIFICATION OF POTENT BH3-MIMETIC COMBINATIONS TARGETING PRO-SURVIVAL PATHWAYS IN HUMAN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Moujalled, Donia, Hanna, Diane, Pomillio, Giovanna, Litalien, Veronique, Fleming, Shaun, Chanrion, Marie, Maragno, Ana-Leticia, Kraus-Berthier, Laurence, Khaw, Seong, Lessene, Guillaume, Huang, David,

Journal:

Experimental Hematology

Année:

2019

Langue:

english

Fichier:

PDF, 65 KB

english, 2019

46

IDENTIFICATION OF POTENT BH3-MIMETIC COMBINATIONS TARGETING PRO-SURVIVAL PATHWAYS IN HUMAN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Moujalled, Donia, Hanna, Diane, Pomillio, Giovanna, Litalien, Veronique, Fleming, Shaun, Chanrion, Marie, Maragno, Ana-Leticia, Kraus-Berthier, Laurence, Khaw, Seong, Lessene, Guillaume, Huang, David,

Journal:

Experimental Hematology

Année:

2019

Fichier:

PDF, 65 KB

2019